In obstructive sleep apnea (OSA), doses approximately 250 mg/day are very well-tolerated but there is no consistent evidence of further profit outside of the one hundred fifty mg/working day.

Define the value of collaboration and interaction among the interprofessional crew users to improve results and cure efficacy for clients who may well get pleasure from therapy with modafinil.

C: Use with caution if Advantages outweigh risks. Animal reports display threat and human scientific tests not obtainable or neither animal nor human scientific studies performed.

Watch Closely (1)triclabendazole will increase the degree or effect of modafinil by impacting hepatic enzyme CYP2C19 metabolism.

Efficacy and protection of adjunctive modafinil treatment on residual too much daytime sleepiness between nasal ongoing favourable airway force-addressed japanese patients with obstructive slumber apnea syndrome: a double-blind placebo-managed examine.[J Clin Snooze Med. 2013]

Utilizing alcohol or tobacco with specific medicines could also result in interactions to happen. Examine together with your Health care professional the usage of your medication with meals, Liquor, or tobacco.

Pediatric Use: Performance and security in pediatric individuals are certainly not proven. Modafinil just isn't FDA-authorized for use within the pediatric population for any sign.

Voxelotor boosts systemic publicity of sensitive CYP3A4 substrates. Stay away from coadministration with sensitive CYP3A4 substrates with a slender therapeutic index. Take into account dose reduction from the delicate CYP3A4 substrate(s) if not able to avoid.

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stiripentol will raise the stage or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Closely. Contemplate reducing get more info the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.

etravirine will minimize the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

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The recommended dosage of modafinil tablets for individuals with narcolepsy or OSA is 200 mg taken orally after daily as only one dose in the morning.

Provigil has not been adequately researched in pregnant Gals and it is actually unidentified whether it is excreted in breast milk. Consult your medical professional in advance of breastfeeding. Supplemental Info